Search on: S6 KINASE 
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Descriptor English:   Ribosomal Protein S6 Kinases 
Descriptor Spanish:   Proteínas Quinasas S6 Ribosómicas 
Descriptor Portuguese:   Proteínas Quinases S6 Ribossômicas 
Synonyms English:   Ribosomal Protein S6 Kinase
S6 H4 Kinase
S6 Kinase
S6-H4 Kinase  
Tree Number:   D08.811.913.696.620.682.700.862
D12.644.360.600
D12.776.476.600
Definition English:   A family of protein serine/threonine kinases which act as intracellular signalling intermediates. Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases. 
See Related English:   Coffin-Lowry Syndrome
Ribosomal Protein S6
 
History Note English:   2003(1998); use RIBOSOMAL PROTEIN S6 KINASES (NM) 1985-1997 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   33474 
Unique Identifier:   D019893 

Occurrence in VHL:
 

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